Abstract: Background – Faecal microbiota transplantation (FMT) is a novel therapy in the field of gastroenterology and is studied at current times with greater curiosity. Objective – To evaluate the efficacy of FMT as GI microbiome restorative therapy in conjunction with symptomatic therapy in parvoviral cases.Animals – Of 258 confirmed cases of CPV, 12 cases were randomly selected and divided into 2 groups (B &C) . Group B was treated with symptomatic therapy whereas Group C was treated with Symptomatic therapy along with FMT as an adjunct therapy.Methods – A randomized case-control study was carried out where animals of Group C (n= 6) were administered with FMT transplant from Day 0 of presentation till Day 7th. Response to FMT was evaluated on the basis of time taken for resolution of diarrhoea, time of hospitalization, clinical scoring, recurrence of gastroenteritis within 2 months post therapy.Results – 66.67% (4/6) dogs of FMT treated group had a quicker resolution of diarrhoea, FMT treated dogs had better clinical scores compared to symptomatic therapy group (1 or clinically insignificant vs 4 or mildly diseased), lesser recurrence of diarrhoea 2 months post therapy in FMT treated group (16.67% vs 50%). Post FMT one case showed low grade fever (n=1) and epistaxis (n=1) which resolved within 24 hours. Mean retention time improved (20.83±2.39) minutes to (140± 12.66) on Day 7th of the trial (p < 0.01). Conclusion – FMT as an adjunct therapy might aid in early resolution of diarrhoea in acute diarrhoea in dogs.
