Alison C. Manchester, DVM, DACVIM (SAIM): No relevant disclosure to display
Presentation Description / Summary: Canine chronic inflammatory enteropathy (CIE) is an extremely prevalent but poorly understood condition. Likely, it encompasses numerous distinct disease entities, but current approaches have not allowed for discernment. During this session, data from single-cell and bulk RNA-sequencing analysis of canine intestinal tissues will be presented with the goal of advancing understanding of CIE pathogenesis and management. We will also incorporate findings from concurrent microbiota sequencing analysis, with the goal of obtaining clinically relevant information from these advanced analytical techniques. A review of different -omics platforms, including their potential gains and limitations, will also be completed. This session will serve as a bridge between benchtop research and clinical conundrums.
Learner Outcomes: 1) Possess a realistic appreciation for the ability of routine histopathology of intestinal biopsies in dogs with CIE to guide patient management.
2) Understand the potential gains, and limitations, associated with analysis of gene expression in intestinal biopsy samples.
3) Appreciate the possible relationships between the intestinal microbiota of dogs with CIE and host mucosal reactions.
Learning Objectives:
Possess a realistic appreciation for the ability of routine histopathology of intestinal biopsies in dogs with CIE to guide patient management.
Understand the potential gains, and limitations, associated with analysis of gene expression in intestinal biopsy samples.
Appreciate the possible relationships between the intestinal microbiota of dogs with CIE and host mucosal reactions.
