Student Chungbuk university Cheongju, Ch'ungch'ong-bukto, Republic of Korea
Abstract:
Background: Radioiodine therapy is crucial for management of feline hyperthyroidism, targeting hyperactive thyroid cells. Efforts to improve the appropriate administration of radioiodine doses have been studied in cats with hyperthyroidism for decades.Hypothesis/
Objectives: The objective of this study was to evaluate the efficacy and safety of individualized dosing adjustment in radioiodine therapy for feline hyperthyroidism, and comparing the outcomes with those achieved through a conventional scoring system.Animals: Forty-one cats were treated with radioiodine based on individualized dosing adjustment, while 18 cats received radioiodine treatment with a previously reported scoring system.
Methods: This study was designed as a comparative cohort study. The individualized dosing adjustment involved the following three-step process: main staging for incorporating scintigraphy findings with serum T4 concentrations, sub-staging for severity of clinical signs, and dose adjustments based on individual condition. Cats treated using the classic scoring system were administered radioiodine based on a previously reported study.
Results: Both treatment groups demonstrated a significant decrease in total T4 levels over time (F (4, 136) = 184.2, p < 0.001), with no significant differences between groups or interaction effects. Conclusions and Clinical Importance: Individualized dosing adjustment demonstrated efficacy similar to the conventional scoring system in treatment for feline hyperthyroidism. This newly designed treatment method could be valuable for optimizing therapeutic outcomes for radioiodine therapy for feline hyperthyroidism.
