Assistant Professor Masonic Cancer Center, Institute for Health Informatics, University of Minnesota Minneapolis, Minnesota, United States
Disclosure(s):
Aaron Sarver: No financial relationships to disclose
Presentation Description / Summary: Osteosarcoma, one of the most common cancers in canines, exhibits complex transcriptional patterns influenced by various driver events. This presentation will explore the factors contributing to these transcriptional profiles, highlighting the mechanisms underlying osteosarcoma development through a comparative oncology approach. Notably, these transcriptional patterns are prognostic for patient outcomes, offering valuable markers for disease progression. Drawing on insights from fifteen published papers and unpublished work, a model is proposed where aging plays a crucial role as the initial driver in the pathogenesis of canine osteosarcoma, setting the stage for subsequent oncogenic transformations. Additionally, syntenic gene ordering has been identified as creating specific osteosarcoma risks in canines. This lecture will also discuss therapeutic vulnerabilities within osteosarcoma, providing insights into potential targets for innovative treatments. Understanding these transcriptional and developmental dynamics is essential for improving diagnostic and therapeutic strategies in osteosarcoma management.
