Douglas H. Thamm, VMD, DACVIM (Oncology): No relevant disclosure to display
Presentation Description / Summary: Macrophages are a pleiotropic cell type that can have diverse pro-tumor and anti-tumor functions depending on their phenotype. This session will discuss macrophage polarization, the role of tumor associated macrophages in tumor control, the prognostic value of monocytes and macrophages, and a review of strategies to target this important cell population.
Learner Outcomes: 1) To become familiar with studies interrogating the effect of circulating monocytes and tumor associated macrophages in canine and feline tumors 2) To understand experimental and clinically available strategies for modulating tumor associated macrophage phenotype and migration
Learning Objectives:
Upon completion, participant will be able to outline the role of tumor associated macrophages in tumor progression and metastasis.
Upon completion, participant will be able to delineate the primary phenotypic characteristics of M1 and M2 macrophages.
Upon completion, participant will be able to list strategies by which tumor associated macrophages can be targeted for cancer therapy.
