Small Animal Internal Medicine Resident The Ohio State University Dublin, OH, United States
Abstract: Background – Porus® One is an oral adsorbent that binds uremic toxin precursors in the gut. The effect of Porus® One on serum amino acid concentrations (sAA) has not been described. Objectives/Hypothesis – Assess the effect of Porus® One on sAA concentrations in cats with CKD. We hypothesized no significant effect on sAA would be observed. Animals – 14 purpose-bred cats (13 IRIS Stage 2, 1 IRIS Stage 3). Methods – Prospective cross-sectional study utilizing cats with remnant kidney model-induced CKD. Cats were treated with consistent standard of care and diet (Days –56 to 0) and then 500 mg Porus® One PO q24h (Days 0 to 28) in food. Twenty-one essential and non-essential sAA were measured on Days –56, -28, 0, and 28 using an ion exchange chromatography amino acid analyzer (Biochrom 30+). sAA were compared between all time points with a Friedman test. Results – There was significant variability in baseline sAA between Days –56, -28, and day 0. Tryptophan was significantly increased at Day 28 (median 68.5 μM, range 49.9-86.6) in comparison to Day 0 (median 60.9 μM, range 45.4-78.1) (p = 0.003). Arginine was significantly decreased at Day 28 (median 100.0 μM, range 67.3-132.9) in comparison to Day 0 (median 115.8 μM, range 63.4-153.0) (p = 0.03). Conclusions and clinical importance – Minimal changes in sAA occurred after administration of Porus® One which are unlikely to be clinically meaningful. Clinicians should anticipate little effect on sAA in the short term with Porus® one supplementation.
