Master`s student School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil/ GastroVet São Paulo, Sao Paulo, Brazil
Abstract:
Background: Yorkshire Terriers have a heightened susceptibility to portosystemic shunt (PSS), and few laboratory parameters can indicate its progression.
Objectives: Comparing routine hematological and biochemical parameters between healthy Yorkshire terriers and Yorkshire terriers with portosystemic shunt at different stages of the disease. ANIMALS: Datasets from a veterinary teaching hospital comprising 22 Yorkshire Terriers at the time of diagnosis of extrahepatic portosystemic shunt (PSS), during the pre-surgical stabilization phase, and post-surgery. These datasets also included 42 client-owned healthy adult Yorkshire Terriers up to 5 years of age, as controls.
Methods: Medical records from Yorkshire terriers with PSS were retrospectively reviewed and compared to datasets of health Yorkshire by non-parametric methods.
Results: In healthy animals, there were higher levels of red blood cells, hemoglobin, hematocrit, hematimetric indices, platelets, total protein, albumin, alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, and creatinine, and lower levels of total leukocytes, neutrophils, and lymphocytes compared to the diseased animals at the time of diagnosis. After treatment, in post-clinical sign absence, animals with PSS exhibited an increase in red blood cells, an increase in mean corpuscular volume (MCV), and a decrease in ALP compared to the time of diagnosis. Dogs after surgery showed an increase in hemoglobin, hematocrit, MCV, mean corpuscular hemoglobin (MCH), total protein, albumin, urea, creatinine, and cholesterol; and a reduction in total leukocytes, neutrophils, monocytes, ALT, and ALP.
Conclusions: Yorkshires with PSS exhibit differences in clinical pathological variables compared to healthy animals, which are minimized over the course of the treatment.
